KWR Anthony Verschoor by KWR Anthony Verschoor
09 July 2018

Specificity of antimicrobials

This study tested different concentrations and combinations of antimicrobials (antibiotics, human-targeted drugs and food additives) on six pathogenic bacteria. Many combinations were species-specific, and sometimes strain-specific. The results reveal drug combinations that enhanced each other (synergies) or that inhibited each other (antagonisms): the former occur more often with drugs targeting the same process. Some of these synergies also were effective against bacteria strains with resistances against multiple antibacterial drugs (antibiotics). This paper improves our understanding of the complex interactions between different antimicrobials, providing new options for targeted medication, even against (multiple) antimicrobial resistance. ...

Species-specific activity of antibacterial drug combinations

Species-specific activity of antibacterial drug combinations Species-specific activity of antibacterial drug combinations, Published online: 04 July 2018; doi:10.1038/s41586-018-0278-9 Screening pairwise combinations of antibiotics and other drugs against three bacterial pathogens reveals that antagonistic and synergistic drug–drug interactions are specific to microbial species and strains. ...

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